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Three cases of acute venous thromboembolism in females after vaccination for coronavirus disease 2019

Published:August 02, 2021DOI:https://doi.org/10.1016/j.jvsv.2021.07.009

      Abstract

      Since December 2020, four vaccines for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) have been developed, and three have been approved for immediate use in the United States. Two are mRNA vaccines, and one uses a viral vector mechanism. Thrombotic complications have been reported after vaccine administration, which were primarily cerebral sinus thromboses after administration of the viral vector vaccines. To the best of our knowledge, we are the first to report venous thrombotic complications within days of administration of the mRNA-1273 (Moderna) vaccine. We present a series of three women who developed venous thromboembolism after RNA-1273 vaccination at a single healthcare system.

      Keywords

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      References

        • Centers for Disease Control and Prevention
        COVID-19 Vaccines.
        (Available at:)
        • Greinacher A.
        • Thiele T.
        • Warkentin T.E.
        • Weisser K.
        • Kyrle P.A.
        • Eichinger S.
        Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination.
        N Engl J Med. 2021; 384: 2092-2101
        • Schultz N.H.
        • Sørvoll I.H.
        • Michelsen A.E.
        • Munthe L.A.
        • Lund-Johansen F.
        • Ahlen M.T.
        • et al.
        Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination.
        N Engl J Med. 2021; 384: 2124-2130
        • Castelli G.P.
        • Pognani C.
        • Sozzi C.
        • Franchini M.
        • Vivona L.
        Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19.
        Crit Care. 2021; 25: 137
        • Marks P.
        • Schuchat A.
        Joint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine.
        (Available at:)
        • Centers for Disease Control and Prevention
        Moderna COVID-19 Vaccine Overview and Safety.
        (Available at:)
        • Sjöström A.
        • Wersäll J.
        • Warnqvist A.
        • Farm M.
        • Magnusson M.
        • Oldner A.
        • et al.
        Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19 [e-pub ahead of print].
        (Thromb Haemost)
        https://doi.org/10.1055/a-1477-3829
        Date accessed: July 12, 2021
        • Li X.
        • Ostropolets A.
        • Makadia R.
        • Shaoibi A.
        • Rao G.
        • Sena A.G.
        • et al.
        Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study [e-pub ahead of print].
        (medRxiv)
        • Erben Y.
        • Franco-Mesa C.
        • Gloviczki P.
        • Stone W.
        • Quinones-Hinojosa A.
        • Meltzer A.J.
        • et al.
        Deep venous thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019 (COVID-19) positive patients predict higher mortality, prolonged intensive care unit and hospital stays in a multi-site healthcare system [e-pub ahead of print].
        (J Vasc Surg Venous Lymphat Disord)
        https://doi.org/10.1016/j.jvsv.2021.03.009
        Date accessed: July 12, 2021
        • Oldenburg J.
        • Klamroth R.
        • Langer F.
        • Albisetti M.
        • von Auer C.
        • Ay C.
        • et al.
        Diagnosis and management of vaccine-related thrombosis following AstraZeneca COVID-19 vaccination: guidance statement from the GTH.
        Hamostaseologie. 2021; 41: 184-189
        • Carli G.
        • Nichele I.
        • Ruggeri M.
        • Barra S.
        • Tosetto A.
        Deep vein thrombosis (DVT) occurring shortly after the second dose of mRNA SARS-CoV-2 vaccine.
        Intern Emerg Med. 2021; 16: 803-804
        • Mosca L.
        • Grady D.
        • Barrett-Connor E.
        • Collins P.
        • Wenger N.
        • Abramson B.L.
        • et al.
        Effect of raloxifene on stroke and venous thromboembolism according to subgroups in postmenopausal women at increased risk of coronary heart disease.
        Stroke. 2009; 40: 147-155
        • Stegeman B.H.
        • de Bastos M.
        • Rosendaal F.R.
        • van Hylckama Vlieg A.
        • Helmerhorst F.M.
        • Stijnen T.
        • et al.
        Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis.
        BMJ. 2013; 347: f5298

      Linked Article

      • Acute venous thromboembolism after COVID-19 vaccination
        Journal of Vascular Surgery: Venous and Lymphatic DisordersVol. 10Issue 1
        • Preview
          We would like to share ideas on “Three cases of acute venous thromboembolism in females following vaccination for COVID-19.”1 Andraska et al concluded that “We present a series of three women who developed venous thromboembolism (VTE) following mRNA-1273 vaccination at a single healthcare system.”1 Pathogenesis of acute venous thromboembolism is an interesting issue. In the present report, mRNA COVID-19 vaccine is used. The autoimmunity development after mRNA COVID-19 vaccine administration is proposed, and it might be mentioned as a cause of thrombotic disorder.
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